Microfluidics-Based Systems in Diagnosis of Alzheimer’s Disease and Biomimetic Modeling

Micromachines

Liqiu Wang¹  Danni Li²  Krishnaswamy Nandakumar³  Pei Zhao³  Yan Li³  Youqiang Song⁴ 

[1] Department of Mechanical Engineering, Faculty of Engineering, The University of Hong Kong, Hong Kong, China;Department of Neurology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250013, China;Energy Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China;School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China;

关键词: Alzheimer’s disease (AD);    microfluidic chips;    AD biomarkers;    blood–brain barrier (BBB);    three-dimensional AD model;   

DOI  :  10.3390/mi11090787

来源: DOAJ

【 摘 要 】

Early detection and accurate diagnosis of Alzheimer’s disease (AD) is essential for patient care and disease treatment. Microfluidic technology is emerging as an economical and versatile platform in disease detection and diagnosis. It can be conveniently integrated with nanotechnology and/or biological models for biomedical functional and pre-clinical treatment study. These strengths make it advantageous in disease biomarker detection and functional analysis against a wide range of biological backgrounds. This review highlights the recent developments and trends of microfluidic applications in AD research. The first part looks at the principles and methods for AD diagnostic biomarker detection and profiling. The second part discusses how microfluidic chips, especially organ-on-a-chip platforms, could be used as an independent approach and/or integrated with other technologies in AD biomimetic functional analysis.

【 授权许可】

Unknown