Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers

Frontiers in Oncology

Ruitai Fan¹  Jiacheng Zhang¹  Kuo Chen¹  Junqi Liu¹  Pengwei Lu¹  Narasimha M. Beeraka²  Chengyun Tang³  Yulia V. Babayeva³  Mikhail Y. Sinelnikov³  Jin Zhang³  Igor V. Reshetov³  Xinliang Zhang³  Olga A. Sukocheva⁴ 

[1] Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), Department of Biochemistry, JSS Academy of Higher Education and Research (JSS AHER), JSS Medical College, Mysuru, India;Department of Human Anatomy, I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia;Discipline of Health Sciences, College of Nursing and Health Sciences, Flinders University, Adelaide, SA, Australia;

关键词: breast cancer;    obesity;    oncogenic signaling;    inflammation;    estrogen;    neoadjuvant therapy;   

DOI  :  10.3389/fonc.2022.820968

来源: DOAJ

【 摘 要 】

Obesity and associated chronic inflammation were shown to facilitate breast cancer (BC) growth and metastasis. Leptin, adiponectin, estrogen, and several pro-inflammatory cytokines are involved in the development of obesity-driven BC through the activation of multiple oncogenic and pro-inflammatory pathways. The aim of this study was to assess the reported mechanisms of obesity-induced breast carcinogenesis and effectiveness of conventional and complementary BC therapies. We screened published original articles, reviews, and meta-analyses that addressed the involvement of obesity-related signaling mechanisms in BC development, BC treatment/prevention approaches, and posttreatment complications. PubMed, Medline, eMedicine, National Library of Medicine (NLM), and ReleMed databases were used to retrieve relevant studies using a set of keywords, including “obesity,” “oncogenic signaling pathways,” “inflammation,” “surgery,” “radiotherapy,” “conventional therapies,” and “diet.” Multiple studies indicated that effective BC treatment requires the involvement of diet- and exercise-based approaches in obese postmenopausal women. Furthermore, active lifestyle and diet-related interventions improved the patients’ overall quality of life and minimized adverse side effects after traditional BC treatment, including postsurgical lymphedema, post-chemo nausea, vomiting, and fatigue. Further investigation of beneficial effects of diet and physical activity may help improve obesity-linked cancer therapies.

【 授权许可】

Unknown