n-3 Polyunsaturated Fatty Acids and Mechanisms to Mitigate Inflammatory Paracrine Signaling in Obesity-Associated Breast Cancer

Nutrients

Jennifer M. Monk¹  Harmony F. Turk²  Danyelle M. Liddle¹  Anna A. De Boer¹  Krista A. Power¹  David W.L. Ma¹ 

[1]Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada

[2] E-Mails:

[3]Institut Curie, Paris 75248, France

[4] E-Mail:

关键词: breast cancer;    inflammation;    obesity;    adipokines;    n-3 polyunsaturated fatty acids;    leptin;    adiponectin;    aromatase;    lipid rafts;    eicosanoids;   

DOI  :  10.3390/nu6114760

来源: mdpi

【 摘 要 】

Globally, the prevalence of obesity is increasing which subsequently increases the risk of the development of obesity-related chronic diseases. Low-grade chronic inflammation and dysregulated adipose tissue inflammatory mediator/adipokine secretion are well-established in obesity, and these factors increase the risk of developing inflammation-associated cancer. Breast cancer is of particular interest given that increased inflammation within the subcutaneous mammary adipose tissue depot can alter the local tissue inflammatory microenvironment such that it resembles that of obese visceral adipose tissue. Therefore, in obese women with breast cancer, increased inflammatory mediators both locally and systemically can perpetuate inflammation-associated pro-carcinogenic signaling pathways, thereby increasing disease severity. Herein, we discuss some of these inflammation-associated pro-carcinogenic mechanisms of the combined obese breast cancer phenotype and offer evidence that dietary long chain n-3 polyunsaturated fatty acids (PUFA) may have utility in mitigating the severity of obesity-associated inflammation and breast cancer.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.