The Emerging Role of Adiponectin in Female Malignancies

International Journal of Molecular Sciences

Stefania Catalano¹  Sebastiano Andò¹  GiuseppinaDaniela Naimo¹  Luca Gelsomino¹  Loredana Mauro¹ 

[1] Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy;

关键词: obesity;    adipokines;    adiponectin;    breast cancer;    ovarian cancer;    endometrial cancer;    cervix cancer;    estrogen receptor;   

DOI  :  10.3390/ijms20092127

来源: DOAJ

【 摘 要 】

Obesity, characterized by excess body weight, is now accepted as a hazardous health condition and an oncogenic factor. In different epidemiological studies obesity has been described as a risk factor in several malignancies. Some biological mechanisms that orchestrate obesity−cancer interaction have been discovered, although others are still not completely understood. The unbalanced secretion of biomolecules, called “adipokines”, released by adipocytes strongly influences obesity-related cancer development. Among these adipokines, adiponectin exerts a critical role. Physiologically adiponectin governs glucose levels and lipid metabolism and is fundamental in the reproductive system. Low adiponectin circulating levels have been found in obese patients, in which its protective effects were lost. In this review, we summarize the epidemiological, in vivo and in vitro data in order to highlight how adiponectin may affect obesity-associated female cancers.

【 授权许可】

Unknown