Clinical features of Guillain–Barré syndrome patients with elevated serum creatine kinase levels

BMC Neurology

Sadaki Sakane¹  Takafumi Hosokawa²  Akihiro Tsukahara²  Yoshitsugu Nakamura²  Shimon Ishida²  Shigeki Arawaka²  Taiki Sawai²  Eri Sano²  Fumiharu Kimura²  Kiichi Unoda²  Hideto Nakajima³ 

[1] Department of Internal Medicine, Hirakata City Hospital;Division of Neurology, Department of Internal Medicine IV, Osaka Medical College;Division of Neurology, Department of Medicine, Nihon University School of Medicine;

关键词: Creatine kinase;    Guillain-Barré syndrome;    AIDP;    AMAN;    Reversible conduction failure;   

DOI  :  10.1186/s12883-020-01796-z

来源: DOAJ

【 摘 要 】

Abstract Background It is not well defined whether Guillain–Barré syndrome (GBS) patients with elevated serum creatine kinase (CK) levels have characteristic clinical features and are related to the subgroups of GBS. Methods We retrospectively studied 51 consecutive patients with GBS, who visited our hospital, and compared clinical, laboratory and electrophysiological findings between patients with and without elevated CK levels. Results Of 51 patients, 14 patients (27%) showed an elevation of serum CK levels. When compared with patients with the normal CK levels, the ratios of male, antecedent infections, and anti-GM1 antibody positivity were significantly higher in patients with elevated CK levels. The ratios of hypoesthesia, cranial nerve involvement, and urinary retention were significantly less in patients with elevated CK levels. There were no significant differences in disability at peak between two groups. In the electrophysiological examination, sensory nerve abnormalities were not observed. Although some patients with elevated CK levels showed prolongation of distal motor latencies (DMLs) and increase of durations in the initial examination, development of the prolongation of DMLs and increase of durations was not observed in the follow-up examinations. The findings were consistent with acute motor axonal neuropathy (AMAN) with reversible conduction failure (RCF) but not acute inflammatory demyelinating polyneuropathy (AIDP). Conclusions The results suggest that the GBS patients with elevated CK levels represent not a group of AIDP but a group of AMAN with axonal degeneration or RCF even though the initial electrophysiological examination shows AIDP pattern.

【 授权许可】

Unknown