COVID-19-related and not related Guillain-Barre syndromes share the same management pitfalls during lock down: The experience of Liguria region in Italy

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:418

Article

Garnero, Martina¹  Del Sette, Massimo²  Assini, Andrea²  Beronio, Alessandro³  Capello, Elisabetta^4,5  Cabona, Corrado⁶  Reni, Lizia⁶  Serrati, Carlo¹  Bandini, Fabio⁷  Granata, Alfredo⁸  Pesce, Giampaola^5,9  Mancardi, Giovanni L.^4,10  Uccelli, Antonio^4,5  Schenone, Angelo^4,5  Benedetti, Luana^4,5 

[1] Imperia Hosp, Dept Neurol, St Agata St 57, I-18100 Imperia, Italy

[2] Galliera Hosp Genova, Neurol Unit, Genoa, Italy

[3] St Andrea Hosp, Dept Neurol, La Spessia, Italy

[4] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

[5] Osped Policlin San Martino, IRCCS, Genoa, Italy

[6] IRCCS Osped Policlin San Martino, Div Clin Neurophysiol, Genoa, Italy

[7] S Paolo Hosp, Dept Neurol, Savona, Italy

[8] Santa Corona Hosp, Dept Neurol, Pietra Ligure, Savona, Italy

[9] Univ Genoa, Dept Internal Med, Genoa, Italy

[10] IRCCS ICS Maugeri, Pavia, Italy

关键词: Guillain-Barre syndrome;    AMAN;    AIDP;    COVID-19;    Miller Fisher;   

DOI  :  10.1016/j.jns.2020.117114

来源: Elsevier

【 摘 要 】

Recently, during the pandemic infection of the novel SARS-CoV-2, some cases of Guillan-Barre Syndrome (GBS) have been reported. The aim of this work is to report the natural history of patients with GBS, both COVID and not-COVID related, hospitalized in Liguria region, during lock down period, in order to assess clinical features of both groups and possible managements pitfalls due to pandemic emergency. Fifteen GBS patients were admitted to the Hospitals of Liguria, from February 15th to May 3rd 2020, six with SARS-CoV-2 infection and nine without infection. In COVID-19 related GBS five patients presented with classical GBS and one with variant. Two patients presented neurologic symptoms during or shortly after the viral syndrome, suggesting the pattern of a para-infectious profile. Multi-organ involvement, delay in the diagnosis, incomplete work up and start of therapy, were registered in 50% of cases with a GBS-Disability scale >= 4 at follow-up evaluation. In not-COVID-19 related GBS, main problem was diagnostic delay. In three patients the first neurological observation took place after a mean of 33,6 days. Moreover, five patients went to emergency room after an average of 30 days since the onset of neurological symptoms because of fear of contagion. In conclusion, not only SARS-CoV-2 infection can cause GBS, but it can also, due to effects of pandemic on the health organization, affect the outcome of patients with not COVID-19 related GBS.

【 授权许可】

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