Glioblastoma, IDH-Wild Type With FGFR3-TACC3 Fusion: When Morphology May Reliably Predict the Molecular Profile of a Tumor. A Case Report and Literature Review

Frontiers in Neurology

Chiara Romano¹  Paolo Vigneri¹  Gaetano Magro³  Giuseppe Broggi³  Francesco Certo⁴  Giuseppe Maria Vincenzo Barbagallo⁴  Roberto Altieri⁴  Dario Condorelli⁵  Elena Tirrò⁶  Eliana Piombino⁷  Cristina Colarossi⁷  Lorenzo Colarossi⁷ 

[1] Center of Experimental Oncology and Hematology, A.O.U. Policlinico “G. Rodolico-San Marco”, Catania, Italy;Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy;Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Anatomic Pathology, University of Catania, Catania, Italy;Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Neurological Surgery, Policlinico “G. Rodolico-San Marco” University Hospital, University of Catania, Catania, Italy;Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Catania, Italy;Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy;Pathology Unit, Department of Experimental Oncology, Mediterranean Institute of Oncology, Catania, Italy;

关键词: FGFR3-TACC3 fusion;    glioblastoma;    unusual morphological features;    molecular biology;    diagnosis;    IDH-wildtype;   

DOI  :  10.3389/fneur.2022.823015

来源: DOAJ

【 摘 要 】

It has been reported that in-frame FGFR3-TACC3 fusions confer to glioblastomas, IDH-wild type (GBMs, IDHwt) some unusual morphologic features, including monomorphous rounded cells with ovoid nuclei, nuclear palisading, endocrinoid network of “chicken-wire” vessels, microcalcifications and desmoplastic stroma, whose observation may predict the molecular profile of the tumor. We herein present a case of recurrent GBMs, IDHwt, exhibiting some of the above-mentioned morphological features and a molecularly-proven FGFR3-TACC3 fusion. A 56-year-old man presented to our hospital for a recurrent GBM, IDHwt, surgically treated at another center. Histologically, the tumor, in addition to the conventional GBM morphology, exhibited the following peculiar morphologic features: (1) monomorphous neoplastic cells with rounded nuclei and scant pale cytoplasm; (2) thin capillary-like vessels with “chicken-wire” pattern; (3) nuclear palisading; (4) formation of vague perivascular pseudorosettes; (5) spindled tumor cells embedded in a loose, myxoid background. Based on this unusual morphology, molecular analyses were performed and an FGFR3 exon17-TACC3 exon 10 fusion was found. The present case contributes to widening the morphologic spectrum of FGFR3-TACC3-fused GBM, IDHwt and emphasizes that pathologists, in the presence of a GBM, IDHwt with unconventional morphology, should promptly search for this fusion gene.

【 授权许可】

Unknown