ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype

Molecular Metabolism

Yulia Haim¹  Nir Goldstein¹  Assaf Rudich¹  Tanya Tarnovscki¹  Iris Shai²  Yftach Gepner²  Nora Klöting³  Matthias Blüher³  Boris Kirshtein⁴  Ilana Harman-Boehm⁵  Daniel Konrad⁶  Doron Ginsberg⁷ 

[1] Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84103, Israel;Department of Epidemiology, Ben-Gurion University of the Negev, Beer-Sheva, 84103, Israel;Department of Medicine, University of Leipzig, 04103, Leipzig, Germany;Department of Surgery A, Soroka Academic Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel;Diabetes Unit, Soroka Academic Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel;Division of Pediatric Endocrinology and Diabetology and Children's Research Center, University Children's Hospital, Zurich, Switzerland;The Mina and Everard Goodman Faculty of Life Science, Bar-Ilan University, Ramat Gan, Israel;

关键词: Obesity;    Transcriptional regulation;    Sub-phenotypes;    Adipose tissue;    Adipocytes;    Stress response;   

DOI  :  10.1016/j.molmet.2017.05.003

来源: DOAJ

【 授权许可】

Unknown