Loss of small heterodimer partner protects against atherosclerosis in apolipoprotein E-deficient mice

Endocrine Journal

Young Joo Park¹  Min Joo Kim¹  Hye Seung Lee²  Ji-Yeon Hwang⁴  Soo Lim¹  Sung Hee Chio¹  Hak Chul Jang¹  Kwan Jae Lee³ 

[1] Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea;Department of Pathology, Seoul National University Bundang Hospital, Seongnam 463-707, Republic of Korea;Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 463-707, Republic of Korea;Preclinical Research Center, Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam 463-707, Republic of Korea

关键词: Small heterodimer partner;    Atherosclerosis;    Obesity;    Adipose tissue;    Cholesterol 7-alpha-hydroxylase;   

DOI  :  10.1507/endocrj.EJ13-0212

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(35)Cited-By(1)Small heterodimer partner (SHP) is involved in bile, lipid, and glucose metabolism.The aim of this study was to investigate the effect of SHP on the development of atherosclerosis.Apolipoprotein E knockout (ApoE-/-) mice were crossed with SHP knockout (SHP-/-) mice to generate double knockout (ApoE-/-SHP-/-) mice.ApoE-/- and ApoE-/-SHP-/- male mice were fed a western diet for 20 weeks.Body weight in ApoE-/-SHP-/- mice was significantly lower than that in ApoE-/- mice (37 ± 1 g vs. 42 ± 1 g, p < 0.01).Loss of SHP in ApoE-/- mice decreased the size of adipocytes in white adipose tissue and reduced lipid accumulation in the liver.Glucose intolerance was improved in ApoE-/-SHP-/- mice as compared with ApoE-/- mice (p < 0.01).There was no statistical difference in non-high density lipoprotein cholesterol levels between ApoE-/-SHP-/- mice and ApoE-/- mice despite an increase of cholesterol 7α-hydroxylase expression in the liver.The proportion of atherosclerotic lesions in the aorta was significantly lower in ApoE-/-SHP-/- mice than in ApoE-/- mice (2.8 ± 2.0% vs. 9.1 ± 1.9%, p < 0.01).In conclusion, loss of SHP function can prevent atherosclerosis, and resistance to diet-induced obesity is the primary factor contributing to this protective effect.

【 授权许可】

Unknown