Targeting gut microbiota: Lactobacillus alleviated type 2 diabetes via inhibiting LPS secretion and activating GPR43 pathway

Journal of Functional Foods

Bao-long Li¹  Shao-Dong Wang²  Jia-Peng Huang²  Yu-Juan Shan³  Kai-Kai Li³  Peng Lei³  Ling Qu³  Pei-Jun Tian⁴ 

[1] Corresponding authors.;Center of Drugs Safety and Evaluation, Heilongjiang University of Chinese Medicine, Harbin, China;Department of Food Science and Engineering, Harbin Institute of Technology, Harbin, China;School of Food Science and Technology, Jiangnan University, Wuxi, China;

关键词: Diabetes;    Gut microbiota;    Probiotics;    Short chain fatty acids;    Intestinal mucous barrier;   

DOI  :  

来源: DOAJ

【 摘 要 】

Lactobacillus G15 and Q14, two species of Lactobacillus used in the preparation of Chinese traditional fermented dairy foods, have the potential to prevent diabetes. Herein, we clarified their mechanisms by which gut microbiota relate to the control of diabetes. Results showed that G15 and Q14 improved the disorders in blood glucose and insulin. Moreover, G15 and Q14 promoted the enrichment of SCFA-producing bacteria, and upregulated the production of acetate and butyrate. Their antidiabetic effects were closely associated with SCFAs-downstream receptors and hormone secretion. Additionally, G15 and Q14 significantly shortened the number of G-negative bacteria, which subsequently decreased the levels of LPS and inflammatory factors. G15 and Q14 improved the disorganization of the intestinal mucous and the integrity of intestinal barrier. Our results indicate that Lactobacillus G15 and Q14 alleviate type 2 diabetes in a gut microbiota-dependent way via downregulating G− bacteria-related LPS secretion, as well as upregulating SCFAs-producing bacteria-related G protein-coupled receptor 43 pathway.

【 授权许可】

Unknown