Development of gut microbiota along with its metabolites of preschool children

BMC Pediatrics

Yong Duan¹  Mei Liu²  Lizhi Zhang²  Hongwei Hu²  Yongkun Huang²  Jingjing Xiong²  Chuanzhi Xu³  Jianwen Yin⁴ 

[1] Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, 650032, Kunming, China;Department of Pediatrics, the First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Xishan District, 650032, Kunming, China;Department of Statistics, School of Public Health, Kunming Medical University, 650000, Kunming, China;Yunnan Center for Disease Control and Prevention, 158 Dongsi Street, Xishan District, 650022, Kunming, Yunnan, China;

关键词: Gut microbiota;    Children development;    Microbial metabolism;    Bile acids;    Short chain fatty acids;   

DOI  :  10.1186/s12887-021-03099-9

来源: Springer

【 摘 要 】

BackgroundTo reveal the changes of intestinal microbial abundance and composition, as well as the microbiota metabolic levels of bile acids and short chain fatty acids of healthy preschool children during their growth.MethodsFeces of 120 healthy newborns and 150 healthy children aged 6 months to 6 years were collected. Then the composition of intestinal flora was analyzed by 16S rRNA, and the contents of bile acids and short chain fatty acids in feces were detected by LC-MS and GS methods, respectively.ResultsThe composition and function of intestinal microflora were not stable in neonatal period but significantly improved at 6 months after birth, and gradually stabilized and tended to adult-like formation after 2–3 years old. The levels of short chain fatty acids and secondary bile acids were consistent with the development of gut microbiota.ConclusionThe age of 6 months may be a critical period for the development of intestinal microflora in children.

【 授权许可】

CC BY