Antioxidant Activity of SOD and Catalase Conjugated with Nanocrystalline Ceria

Bioengineering

Dmitry Gil¹  Jeannette Rodriguez¹  Alexey Vertegel¹  Brendan Ward¹  Vladimir Reukov¹  Vladimir Ivanov² 

[1] Department of Bioengineering, Clemson University, 301 Rhodes Hall, Clemson, SC 29634, USA;Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr. 31, 119991 Moscow, Russia;

关键词: nanoceria;    antioxidants;    superoxide dismutase;   

DOI  :  10.3390/bioengineering4010018

来源: DOAJ

【 摘 要 】

Interactions of nanoparticles with biological matter—both somatically and in nature—draw scientists’ attention. Nanoparticulate systems are believed to be our saviors, acting as versatile drug delivery vehicles. However, they can also cause life-threatening bodily damage. One of the most important properties of nanocrystalline cerium dioxide is its antioxidant activity, which decreases the abundance of reactive oxygen species during inflammation. In this paper, we report on synergistic effects of inorganic cerium oxide (IV) nanoparticles conjugated with the antioxidative enzymes superoxide dismutase and catalase on scavenging oxygen and nitrogen radicals.

【 授权许可】

Unknown