A New Benzofuran Glycoside and Indole Alkaloids from a Sponge-Associated Rare Actinomycete, Amycolatopsis sp.

Marine Drugs

Byung-Yong Kim¹  Ki-Bong Oh²  Jongheon Shin³  Yun Kwon³  Dong-Chan Oh³  Seong-Hwan Kim³  Sang Kook Lee³  Munhyung Bae³  Yoonho Shin³ 

[1] ChunLab, Inc., Seoul National University, Seoul, 151-742, Korea;Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul 151-921, Korea;Natural Products Research Institute, College of Pharmacy, Seoul National University,Seoul 151-742, Korea;

关键词: sponge;    rare actinomycete;    Amycolatopsis;    benzofuran;    cyclopiazonic acid;   

DOI  :  10.3390/md12042326

来源: DOAJ

【 摘 要 】

Three new secondary metabolites, amycofuran (1), amycocyclopiazonic acid (2), and amycolactam (3), were isolated from the sponge-associated rare actinomycete Amycolatopsis sp. Based on combined spectroscopic analyses, the structures of 1–3 were determined to be a new benzofuran glycoside and new indole alkaloids related to cyclopiazonic acids, a class that has previously only been reported in fungi. The absolute configurations of 1 and 3 were deduced by ECD calculations, whereas that of 2 was determined using the modified Mosher method. Amycolactam (3) displayedsignificant cytotoxicity against the gastric cancer cell line SNU638 and the colon cancercell line HCT116.

【 授权许可】

Unknown