Embedded Upconversion Nanoparticles in Magnetic Molecularly Imprinted Polymers for Photodynamic Therapy of Hepatocellular Carcinoma

Biomedicines

Jia-Xin Yu¹  Chien-Yu Lin¹  Tzong-Liu Wang¹  Yu-Hua Chang¹  Hung-Yin Lin¹  Mei-Hwa Lee²  James L. Thomas³  Cheng-Chih Lin⁴ 

[1] Department of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung 81148, Taiwan;Department of Materials Science and Engineering, I-Shou University, Kaohsiung 84001, Taiwan;Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, USA;Division of Pulmonary Medicine, Department of Internal Medicine, Armed-Forces Zuoying General Hospital, Kaohsiung 81342, Taiwan;

关键词: upconversion nanoparticles;    peptide-imprinted polymer;    composite particles;    photodynamic therapy;   

DOI  :  10.3390/biomedicines9121923

来源: DOAJ

【 摘 要 】

In this work, high-temperature pyrolysis was used to prepare both the core and shell of lantha-nide-doped UCNPs with lithium yttrium tetrafluoride (LiYF₄) to enhance the green luminescence. Merocyanine 540 (MC540)-grafted magnetic nanoparticles were incorporated in the PD-L1 pep-tide-imprinted poly(ethylene-co-vinyl alcohol) particles, which were formed by precipitation in a non-solvent. UCNPs in the non-solvent bath were thus entrapped in the imprinted particles to generate composite nanoparticles for the targeting and photodynamic therapy of PD-L1 in tumor cells. Finally, the in vitro cytotoxicity of the nanoparticles in HepG2 human liver cancer cells was evaluated with the continuous administration of MC540/MNPs@MIPs/UCNPs under irradiation by an NIR laser. To understand the delivery of the UCNP-embedded molecularly imprinted pol-ymers, the intrinsic and extrinsic pathways were also investigated.

【 授权许可】

Unknown