Biomedicines | |
Embedded Upconversion Nanoparticles in Magnetic Molecularly Imprinted Polymers for Photodynamic Therapy of Hepatocellular Carcinoma | |
Jia-Xin Yu1  Chien-Yu Lin1  Tzong-Liu Wang1  Yu-Hua Chang1  Hung-Yin Lin1  Mei-Hwa Lee2  James L. Thomas3  Cheng-Chih Lin4  | |
[1] Department of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung 81148, Taiwan;Department of Materials Science and Engineering, I-Shou University, Kaohsiung 84001, Taiwan;Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, USA;Division of Pulmonary Medicine, Department of Internal Medicine, Armed-Forces Zuoying General Hospital, Kaohsiung 81342, Taiwan; | |
关键词: upconversion nanoparticles; peptide-imprinted polymer; composite particles; photodynamic therapy; | |
DOI : 10.3390/biomedicines9121923 | |
来源: DOAJ |
【 摘 要 】
In this work, high-temperature pyrolysis was used to prepare both the core and shell of lantha-nide-doped UCNPs with lithium yttrium tetrafluoride (LiYF4) to enhance the green luminescence. Merocyanine 540 (MC540)-grafted magnetic nanoparticles were incorporated in the PD-L1 pep-tide-imprinted poly(ethylene-co-vinyl alcohol) particles, which were formed by precipitation in a non-solvent. UCNPs in the non-solvent bath were thus entrapped in the imprinted particles to generate composite nanoparticles for the targeting and photodynamic therapy of PD-L1 in tumor cells. Finally, the in vitro cytotoxicity of the nanoparticles in HepG2 human liver cancer cells was evaluated with the continuous administration of MC540/MNPs@MIPs/UCNPs under irradiation by an NIR laser. To understand the delivery of the UCNP-embedded molecularly imprinted pol-ymers, the intrinsic and extrinsic pathways were also investigated.
【 授权许可】
Unknown