The Use of Upconversion Nanoparticles in Prostate Cancer Photodynamic Therapy

Life

Michał Osuchowski¹  Filip Osuchowski¹  Aleksandra Kawczyk-Krupka²  Wojciech Latos³ 

[1] College of Medical Sciences, University of Rzeszów, 35-310 Rzeszów, Poland;Department of Internal Medicine, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia in Katowice, 41-902 Bytom, Poland;Specialistic Hospital No. 2, 41-902 Bytom, Poland;

关键词: upconversion nanoparticles;    UCNPs;    prostate cancer;    photodynamic therapy;    PDT;   

DOI  :  10.3390/life11040360

来源: DOAJ

【 摘 要 】

Photodynamic Therapy (PDT) is a cancer treatment that uses light, a photosensitizer, and oxygen to destroy tumors. This article is a review of approaches to the treatment of prostate cancer applying upconversion nanoparticles (UCNPs). UCNPs have become a phenomenon that are rapidly gaining recognition in medicine. They have proven to be highly selective and specific and present a powerful tool in the diagnosis and treatment of prostate cancer. Prostate cancer is a huge health problem in Western countries. Its early detection can significantly improve patients’ prognosis, but currently used diagnostic methods leave much to be desired. Recently developed methodologies regarding UCNP research between the years 2021 and 2014 for prostate cancer PDT will also be discussed. Current limitations in PDT include tissue irradiation with visible wavelengths that have a short tissue penetration depth. PDT with the objectives to synthesize UCNPs composed of a lanthanide core with a coating of adsorbed dye that will generate fluorescence after excitation with near-infrared light to illuminate deep tissue is a subject of intense research in prostate cancer.

【 授权许可】

Unknown