Biliverdin reductase: more than a namesakeThe reductase, its peptide fragments and biliverdin regulate activity of the three classes of protein kinase C.

Frontiers in Pharmacology

Cicerone eTudor¹  Peter E.M. Gibbs²  Mahin D Maines² 

[1] Max Planck Institute for Immunobiology and Epigenetics;University of Rochester School of Medicine and Dentistry;

关键词: Peptides;    Protein Kinase C;    Biliverdin Reductase;    Signaling Pathways;    Biliverdin;   

DOI  :  10.3389/fphar.2012.00031

来源: DOAJ

【 摘 要 】

The expanse of human biliverdin reductase (hBVR) functions in the cells is arguably umatched by any single protein. hBVR is a Ser/Thr/Tyr kinase, a scaffold protein, a transcription factor and anintracellular transporter of gene regulators. hBVR is an upstream activator of the insulin/IGF-1 signaling pathway and of PKC kinases in the two major arms of the pathway. In addition, it is the sole means for generating the antioxidant bilirubin-IXα. hBVR is essential for activation of ERK1/2 kinases by upstream MAPKK-MEK and by PKCδ, as well as the nuclear import and export of ERK1/2. Small fragments of hBVR are potent activators and inhibitors of the ERK kinases and PKCs: as such, they suggest the potential application of BVR-based technology in therapeutic settings. Presently, we have reviewed the function of hBVR in cell signaling with an emphasis on regulation of PKCδ activity.

【 授权许可】

Unknown