Biomolecular Detection Based on the Rotational Dynamics of Magneto-Plasmonic Nanoparticles

Proceedings

Pia Schneeweiss¹  Astrit Shoshi¹  Thomas Glatzl¹  Judith Schinerl¹  Hubert Brueckl¹  Gábor Kovács¹  Michael Muehlberger²  Michael J. Haslinger² 

[1] Center for Integrated Sensor Systems, Danube University Krems, 2700 Wr. Neustadt, Austria;PROFACTOR GmbH, 4407 Steyr-Gleink, Austria;

关键词: Magnetic-Lab-on-a-Bead;    biosensor;    nanoparticle;    magnetic;    plasmonic;    point-of-care diagnostics;    nanoimprint lithography;    homogeneous immunoassay;   

DOI  :  10.3390/proceedings1040541

来源: DOAJ

【 摘 要 】

We report on a nanoparticle-based biosensor that represents a label-free homogeneous bioassay suitable for in-vitro biomolecular diagnostics. The underlying detection principle is based on the optical observation of the rotational dynamics of multicomponent nanoparticles utilizing magnetic and plasmonic properties. The plasmon-optical properties of the anisotropic nanoparticles depending on their material composition and geometrical design were investigated by numerical simulations. Based on such an analysis, monodisperse magneto-plasmonic nanoparticles were fabricated using physical fabrication methods. Rotational dynamics measurements revealed the lowest detectable particle concentration in the picomolar (ng/mL) regime, which is very promising in reaching the biomolecular limit of detection which is relevant for routine clinical diagnostics.

【 授权许可】

Unknown