Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2

Nutrients

Masutaka Furue¹  Takahito Chiba¹  Hiroshi Uchi¹  Chikage Mitoma¹  Takamichi Ito¹  Gaku Tsuji¹  Takeshi Nakahara¹  Akiko Hashimoto-Hachiya¹ 

[1] Department of Dermatology, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan;

关键词: antioxidants;    reactive oxygen species;    aryl hydrocarbon receptor;    nuclear factor-erythroid 2-related factor-2;    phytochemicals;   

DOI  :  10.3390/nu9030223

来源: DOAJ

【 摘 要 】

Skin is the outermost part of the body and is, thus, inevitably exposed to UV rays and environmental pollutants. Oxidative stress by these hazardous factors accelerates skin aging and induces skin inflammation and carcinogenesis. Aryl hydrocarbon receptors (AHRs) are chemical sensors that are abundantly expressed in epidermal keratinocytes and mediate the production of reactive oxygen species. To neutralize or minimize oxidative stress, the keratinocytes also express nuclear factor-erythroid 2-related factor-2 (NRF2), which is a master switch for antioxidant signaling. Notably, there is fine-tuned crosstalk between AHR and NRF2, which mutually increase or decrease their activation states. Many NRF2-mediated antioxidant phytochemicals are capable of up- and downmodulating AHR signaling. The precise mechanisms by which these phytochemicals differentially affect the AHR and NRF2 system remain largely unknown and warrant future investigation.

【 授权许可】

Unknown