Long Non-Coding RNA: Dual Effects on Breast Cancer Metastasis and Clinical Applications

Cancers

Xian-Ling Qian¹  Li-Xia Xiong¹  Qing-Yun Huang¹  Qi-Yuan Huang¹  Li-Bo Tang¹  Guo-Feng Liu² 

[1] Department of Pathophysiology, Basic Medical College, Nanchang University, Nanchang 330006, China;First Clinical Medical College, Nanchang University, Nanchang 330006, China;

关键词: lncrna;    breast cancer;    metastasis;    cancer stem cell;    angiogenesis;    chemotherapy resistance;    prognosis;   

DOI  :  10.3390/cancers11111802

来源: DOAJ

【 摘 要 】

As a highly heterogeneous malignancy, breast cancer (BC) has become the most significant threat to female health. Distant metastasis and therapy resistance of BC are responsible for most of the cases of mortality and recurrence. Distant metastasis relies on an array of processes, such as cell proliferation, epithelial-to-mesenchymal transition (EMT), mesenchymal-to-epithelial transition (MET), and angiogenesis. Long non-coding RNA (lncRNA) refers to a class of non-coding RNA with a length of over 200 nucleotides. Currently, a rising number of studies have managed to investigate the association between BC and lncRNA. In this study, we summarized how lncRNA has dual effects in BC metastasis by regulating invasion, migration, and distant metastasis of BC cells. We also emphasize that lncRNA has crucial regulatory effects in the stemness and angiogenesis of BC. Clinically, some lncRNAs can regulate chemotherapy sensitivity in BC patients and may function as novel biomarkers to diagnose or predict prognosis for BC patients. The exact impact on clinical relevance deserves further study. This review can be an approach to understanding the dual effects of lncRNAs in BC, thereby linking lncRNAs to quasi-personalized treatment in the future.

【 授权许可】

Unknown