Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

Molecules

关键词: Trifluoromethylpyrazole;    glucopyranose;    antitumor agents.;   

DOI  :  10.3390/90300109

来源: DOAJ

【 摘 要 】

2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line.

【 授权许可】

Unknown