Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4-dihydropyrazol-3-one Nucleosides

Molecules

Ibrahim M. Abdou¹  Ayman M. Saleh² 

[1] Department of Biochemistry, Faculty of Medicine & Health Sciences, UAE University, Al-Ain P.O. Box 17666, UAE.

关键词: Trifluoromethylpyrazole;    glucopyranose;    antitumor agents;   

DOI  :  10.3390/90300109

来源: mdpi

【 摘 要 】

2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by ¹H and ¹³C-NMR spectroscopy. Glucoside 3b shows an in vitro IC₅₀ value of 16.4 µM against proliferation of the human promyelotic leukemia (HL60) cell line.

【 授权许可】

Unknown   
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