Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

Molecular Cancer

Chen Zhang¹  Shidai Jin¹  Renhua Guo¹  Xinyin Liu¹  Yi Chen¹ 

[1] Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital;

关键词: Ferroptosis;    Chemotherapy;    Targeted therapy;    Immunotherapy;    Drug resistance;   

DOI  :  10.1186/s12943-022-01530-y

来源: DOAJ

【 摘 要 】

Abstract Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a pivotal role in tumor suppression, thus providing new opportunities for cancer therapy. The development of resistance to cancer therapy remains a major challenge. A number of preclinical and clinical studies have focused on overcoming drug resistance. Intriguingly, ferroptosis has been correlated with cancer therapy resistance, and inducing ferroptosis has been demonstrated to reverse drug resistance. Herein, we provide a detailed description of the mechanisms of ferroptosis and the therapeutic role of regulating ferroptosis in reversing the resistance of cancer to common therapies, such as chemotherapy, targeted therapy and immunotherapy. We discuss the prospect and challenge of regulating ferroptosis as a therapeutic strategy for reversing cancer therapy resistance and expect that our review could provide some references for further studies.

【 授权许可】

Unknown