Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

Molecular Cancer

Renhua Guo¹  Chen Zhang¹  Shidai Jin¹  Xinyin Liu¹  Yi Chen² 

[1] Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, 300 Guangzhou Road, Nanjing, Jiangsu Province, China;Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, 300 Guangzhou Road, Nanjing, Jiangsu Province, China;Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, Jiangsu, China;

关键词: Ferroptosis;    Chemotherapy;    Targeted therapy;    Immunotherapy;    Drug resistance;   

DOI  :  10.1186/s12943-022-01530-y

来源: Springer

【 摘 要 】

Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a pivotal role in tumor suppression, thus providing new opportunities for cancer therapy. The development of resistance to cancer therapy remains a major challenge. A number of preclinical and clinical studies have focused on overcoming drug resistance. Intriguingly, ferroptosis has been correlated with cancer therapy resistance, and inducing ferroptosis has been demonstrated to reverse drug resistance. Herein, we provide a detailed description of the mechanisms of ferroptosis and the therapeutic role of regulating ferroptosis in reversing the resistance of cancer to common therapies, such as chemotherapy, targeted therapy and immunotherapy. We discuss the prospect and challenge of regulating ferroptosis as a therapeutic strategy for reversing cancer therapy resistance and expect that our review could provide some references for further studies.

【 授权许可】

CC BY