期刊论文详细信息
Clinical Epigenetics
Finding an easy way to harmonize: a review of advances in clinical research and combination strategies of EZH2 inhibitors
Yan Wang1  Yueqing Gong1  Zhen Tan2  Chen Li3  Tengrui Zhang3  Jiaqi Huang3  Lixiang Xue3 
[1] Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, 49 North Garden Road, Haidian District, 100191, Beijing, China;Department of Bone and Joint Surgery, Peking University Shenzhen Hospital, 518036, Shenzhen, People’s Republic of China;Department of Radiation Oncology, Peking University Third Hospital, 100191, Beijing, China;Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, 49 North Garden Road, Haidian District, 100191, Beijing, China;
关键词: EZH2;    EZH2 inhibitors;    Combination therapy;    Immunotherapy;    Chemotherapy;    Targeted therapy;    Endocrine therapy;    Cancer epigenetics;   
DOI  :  10.1186/s13148-021-01045-1
来源: Springer
PDF
【 摘 要 】

Enhancer of zeste homolog 2 inhibitors (EZH2i) have garnered increased attention owing to their anticancer activity by targeting EZH2, a well-known cancer-promoting factor. However, some lymphomas are resistant to EZH2i, and EZH2i treatment alone is ineffective in case of EZH2-overexpressing solid tumors. The anti-cancer efficacy of EZH2i may be improved through safe and effective combinations of these drugs with other treatment modalities. Preclinical evidence indicates that combining EZH2i with other therapies, such as immunotherapy, chemotherapy, targeted therapy, and endocrine therapy, has complementary or synergistic antitumor effects. Therefore, elucidating the underlying mechanisms of the individual constituents of the combination therapies is fundamental for their clinical application. In this review, we have summarized notable clinical trials and preclinical studies using EZH2i, their progress, and combinations of EZH2i with different therapeutic modalities, aiming to provide new insights for tumor treatment.

【 授权许可】

CC BY   

【 预 览 】
附件列表
Files Size Format View
RO202107025437843ZK.pdf 1063KB PDF download
  文献评价指标  
  下载次数:1次 浏览次数:1次