Mesenchymal Stromal Cells Preconditioning: A New Strategy to Improve Neuroprotective Properties

International Journal of Molecular Sciences

Emanuela Mazzon¹  Giovanni Schepici¹  Agnese Gugliandolo¹ 

[1] IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy;

关键词: mesenchymal stromal cells;    preconditioning;    neurological diseases;    neurogenesis;    transplant;   

DOI  :  10.3390/ijms23042088

来源: DOAJ

【 摘 要 】

Neurological diseases represent one of the main causes of disability in human life. Consequently, investigating new strategies capable of improving the quality of life in neurological patients is necessary. For decades, researchers have been working to improve the efficacy and safety of mesenchymal stromal cells (MSCs) therapy based on MSCs’ regenerative and immunomodulatory properties and multilinear differentiation potential. Therefore, strategies such as MSCs preconditioning are useful to improve their application to restore damaged neuronal circuits following neurological insults. This review is focused on preconditioning MSCs therapy as a potential application to major neurological diseases. The aim of our work is to summarize both the in vitro and in vivo studies that demonstrate the efficacy of MSC preconditioning on neuronal regeneration and cell survival as a possible application to neurological damage.

【 授权许可】

Unknown