Phytochemistry and potential therapeutic actions of Boswellic acids: A mini-review

Asian Pacific Journal of Tropical Biomedicine

Asif Husain¹  Farah Iram¹  Shah Alam Khan² 

[1] Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Jamia Hamdard (Hamdard University), New Delhi 110062, India;Department of Pharmacy, Oman Medical College, PO Box 620, PC 130, Muscat, Oman;

关键词: Boswellia serrata;    Boswellic acids;    Inflammation;    Leukotriene synthesis;    5-Lipoxygenase;   

DOI  :  10.1016/j.apjtb.2017.05.001

来源: DOAJ

【 摘 要 】

The pentacyclic triterpenic acids isolated from the oleo gum resin of various Boswellia species are collectively called as Boswellic acids (BA). The oleo gum resin obtained from Indian variety i.e. Boswellia serrata (Family – Burseraceae) is commonly known as Salai guggal. The resin fraction of Salai guggal is rich in Boswellic acids and its essential oil is composed of a mixture of mono, di and sesquiterpenes while gum fraction chiefly contains pentose and hexose sugars. This oleo-gum resin is quite popular among traditional practitioners of traditional Chinese and Indian Systems of medicine owing to their wide range of useful biological properties such as anti-inflammatory, anti-arthritic, anti-rheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, anti-microbial anti-fungal, anti-complementary and analgesic activity, etc. It has been used as a herbal medicine since the prehistoric time to cure acute and chronic ailments including inflammatory diseases. Phytochemical investigation of this herbal medicine lead to identification of Boswellic acids which are found to be novel, potent, specific anti-inflammatory agents due to non-redox inhibition of 5-lipoxygenase (5-LO) enzyme. However, the other important targets of Boswellic acids also include topoisomerases, angiogenesis, and cytochrome p450 enzymes. This review is a sincere attempt to discuss and present the current status of therapeutic potential, phytochemical as well as pharmacological profile of Boswellic acids primarily obtained from B. serrata.

【 授权许可】

Unknown