Regional distribution of leukotriene and mono‐hydroxyeicosatetraenoic acid production in the rat brain Highest leukotriene C4 formation in the hypothalamus

FEBS Letters

Hökfelt, Tomas²  Samuelsson, Bengt¹  Lindgren, Jan Åke¹  Miyamoto, Tsumoru¹ 

[1] Department of Physiological Chemistry, Karolinska Institutet, S-104 01 Stockholm, Sweden;Department of Histology, Karolinska Institutet, S-104 01 Stockholm, Sweden

关键词: Hypothalamus;    Lipoxygenase product;    Leukotriene synthesis;    (Rat brain);    5-HETE;    5-hydroxy-6;    8;    11;    14-eicosatetraenoic acid;    9-HETE;    9-hydroxy-5;    7;    11;    14-eicosatetraenoic acid;    11-HETE;    11-hydroxy-5;    8;    12;    14-eicosatetraenoic acid;    12-HETE;    12-hydroxy-6;    8;    10;    14-eicosatetraenoic acid;    15-HETE;    15-hydroxy-5;    8;    11;    13-eicosatetraenoic acid.;   

DOI  :  10.1016/0014-5793(87)80769-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The regional distribution of ionophore A23187-induced synthesis of leukotrienes and mono-hydroxyeicosatetraenoic acids in the rat brain in vitro was investigated. Pronounced differences in leukotriene C₄ formation were observed, with the highest synthetic capacity in the hypothalamus. The formation of leukotriene C₄ was about 12-times higher in the hypothalamus as compared to the cerebellum. This finding is in agreement with a possible neuroendocrine role for leukotriene C₄. In contrast, the activity of leukotriene B₄ synthesis was widely distributed without pronounced regional differences in the rat brain. Formation of 5-, 9-, 11-, 12- and 15-monohydroxyeicosatetraenoic acid was detected in all regions. The major lipoxygenase product in the hypothalamus and thalamus was 5-hydroxyeicosatetraenoic acid, while other monohydroxyeicosatetraenoic acids predominated in the remaining regions tested.

【 授权许可】

Unknown