Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma

EJNMMI Physics

Yukito Maeda¹  Nobuyuki Kudomi²  Keisuke Miyake³  Tetsuhiro Hatakeyama³  Yoshihiro Nishiyama⁴  Yuka Yamamoto⁴  Katsuya Mitamura⁴  Takashi Norikane⁴ 

[1] Department of Clinical Radiology, Kagawa University Hospital;Department of Medical Physics, Faculty of Medicine, Kagawa University;Department of Neurological Surgery, Faculty of Medicine, Kagawa University;Department of Radiology, Faculty of Medicine, Kagawa University;

关键词: Fractal analysis;    Glioma;    PET;    11C-methionine;    Grading;    IDH1;   

DOI  :  10.1186/s40658-021-00418-y

来源: DOAJ

【 摘 要 】

Abstract Background The present study tested the possible utility of fractal analysis from l-[methyl-11C]-methionine (MET) uptake in patients with newly diagnosed gliomas for differentiating glioma, especially in relation to isocitrate dehydrogenase 1 (IDH1) mutation status, and as compared with the conventional standardized uptake value (SUV) parameters. Methods Investigations of MET PET/CT were performed retrospectively in 47 patients with newly diagnosed glioma. Tumors were divided into three groups: lower grade glioma (IDH1-mutant diffuse astrocytoma and IDH1-mutant anaplastic astrocytoma), higher grade glioma (IDH1-wildtype diffuse astrocytoma and IDH1-wildtype anaplastic astrocytoma), and glioblastoma. The fractal dimension for tumor, maximum SUV (SUVmax) for tumor (T) and mean SUV for normal contralateral hemisphere (N) were calculated, and the tumor-to-normal (T/N) ratio was determined. Metabolic tumor volume (MTV) and total lesion MET uptake (TLMU) were also measured. Results There were significant differences in SUVmax (p = 0.006) and T/N ratio (p = 0.02) between lower grade glioma and glioblastoma. There were no significant differences among any of the three groups in MTV or TLMU. Significant differences were obtained in the fractal dimension between lower grade glioma and higher grade glioma (p = 0.006) and glioblastoma (p < 0.001). Conclusions The results of this preliminary study in a small patient population suggest that the fractal dimension using MET PET in patients with newly diagnosed gliomas is useful for differentiating glioma, especially in relation to IDH1 mutation status, which has not been possible with SUV parameters.

【 授权许可】

Unknown