Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones

Molecules

Zhu-Lian Wu¹  Wei Wen¹  Tian Cai¹  Yu-Zu Zhang¹  Yu-Hao Zhou¹  Qi-Xiang Guo¹ 

[1] Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China;

关键词: organocatalysis;    aldol reaction;    asymmetric synthesis;    2,3-dihydroxy-1,4-dione;    arylglyoxal;   

DOI  :  10.3390/molecules25030648

来源: DOAJ

【 摘 要 】

A highly efficient quinine-derived primary-amine-catalyzed asymmetric aldol addition of hydroxyacetone to arylglyoxals is described. Structurally diverse anti-2,3-dihydroxy-1,4-diones were generated in high yields, with good diastereoselectivities and enantioselectivities.

【 授权许可】

Unknown