Novel chiral ionic liquid (CIL) assisted selectivity enhancement to (L)-proline catalyzed asymmetric aldol reactions

Journal of the Brazilian Chemical Society

Long Zhang¹  Haibo Zhang¹  Huadong Luo¹  Xiaohai Zhou¹  Gongzhen Cheng¹ 

[1] ,Wuhan University College of Chemistry

关键词: aldol reaction;    asymmetric synthesis;    chiral ionic liquids;    chiral additive;   

DOI  :  10.1590/S0103-50532011000900016

来源: SciELO

【 摘 要 】

A significant improvement of the chemical yields (up to 88%), stereoselectivity (> 99:1) and enantiomeric excesses (up to 98%) of (L)-proline catalyzed direct asymmetric aldol reaction was found when proline based chiral ionic liquids (CILs) were added as additives. Different ratios of DMSO/H2O as solvent and chiral ionic liquids (CILs) with chiral cations of different chain length were investigated

【 授权许可】

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