Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology

Journal of Clinical Medicine

IngerJohanne Bakken¹  Fernando Estévez-López²  Nuno Sepúlveda³  Luis Nacul³  Kathleen Mudie³  Eliana Lacerda³  Enrica Capelli⁴  Joanna Słomko⁵  Paweł Zalewski⁵  Slobodan Sekulic⁶  Evelina Shikova⁷  ElinBolle Strand⁸  Derek Pheby⁹  Carmen Scheibenbogen^1,10  Modra Murovska^1,11  Jose Alegre^1,12  Jesús Castro-Marrero^1,12  Lorenzo Lorusso^1,13  Andrejs Ivanovs^1,14  Xia Wang-Steverding^1,15 

[1] Centre for Fertility and Health (CeFH), Norwegian Institute of Public Health, 0456 Oslo, Norway;Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands;Department of Clinical Research, Faculty of Infectious & Tropical Disease, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK;Department of Earth and Environmental Sciences and Centre for Health Technologies, University of Pavia, 27100 Pavia, Italy;Department of Hygiene, Epidemiology, Ergonomics and Postgraduate Education, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-094 Bydgoszcz, Poland;Department of Neurology, Medical Faculty Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia;Department of Virology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria & The National Specialized Hospital for Active Treatment in Haematological Diseases, 1233 Sofia, Bulgaria;Faculty of Health Studies, VID Specialized University, 0370 Oslo, Norway;Faculty of Health and Society, Buckinghamshire New University, High Wycombe HP11 3JZ, UK;Institute for Medical Immunology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany;Institute of Microbiology and Virology, Riga Stradins University, LV-1007 Riga, Latvia;ME/CFS Unit, Division of Rheumatology, Vall d’Hebron Hospital Research Institute (VHIR), Universitat Autònoma de Barcelona, 08035 Barcelona, Spain;Neurology Department, ASST-Lecco, 23807 Merate, Italy;Statistics Unit, Riga Stradins University, LV-1007 Riga, Latvia;Warwick Medical School, University of Warwick, Coventry CV4 7HL, UK;

关键词: central nervous system diseases;    infections;    muscular diseases;    post-exertional malaise;    virus diseases;   

DOI  :  10.3390/jcm9051557

来源: DOAJ

【 摘 要 】

This review aimed at determining the prevalence and incidence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in Europe. We conducted a primary search in Scopus, PubMed and Web of Science for publications between 1994 and 15 June 2019 (PROSPERO: CRD42017078688). Additionally, we performed a backward-(reference lists) and forward-(citations) search of the works included in this review. Grey literature was addressed by contacting all members of the European Network on ME/CFS (EUROMENE). Independent reviewers searched, screened and selected studies, extracted data and evaluated the methodological and reporting quality. For prevalence, two studies in adults and one study in adolescents were included. Prevalence ranged from 0.1% to 2.2%. Two studies also included incidence estimates. In conclusion, studies on the prevalence and incidence of ME/CFS in Europe were scarce. Our findings point to the pressing need for well-designed and statistically powered epidemiological studies. To overcome the shortcomings of the current state-of-the-art, EUROMENE recommends that future research is better conducted in the community, reviewing the clinical history of potential cases, obtaining additional objective information (when needed) and using adequate ME/CFS case definitions; namely, the Centers for Disease Control & Prevention−1994, Canadian Consensus Criteria, or Institute of Medicine criteria.

【 授权许可】

Unknown