Genistein: A Potent Anti-Breast Cancer Agent

Current Issues in Molecular Biology

Shashanka K. Prasad¹  Smitha S. Bhat¹  Chandan Shivamallu¹  Pruthvish Reddy²  Asad Syed³  Raghavendra G. Amachawadi⁴  Kollur Shiva Prasad⁵  Charley A. Cull⁶ 

[1] Department of Biotechnology and Bioinformatics, Faculty of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India;Department of Biotechnology, Acharya Institute of Technology, Bengaluru 560107, Karnataka, India;Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA;Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru 570026, Karnataka, India;Midwest Veterinary Services, Inc., Oakland, NE 68045, USA;

关键词: genistein;    apoptosis;    breast cancer;    cell cycle;    estrogen receptor;   

DOI  :  10.3390/cimb43030106

来源: DOAJ

【 摘 要 】

Genistein is an isoflavonoid present in high quantities in soybeans. Possessing a wide range of bioactives, it is being studied extensively for its tumoricidal effects. Investigations into mechanisms of the anti-cancer activity have revealed many pathways including induction of cell proliferation, suppression of tyrosine kinases, regulation of Hedgehog-Gli1 signaling, modulation of epigenetic activities, seizing of cell cycle and Akt and MEK signaling pathways, among others via which the cancer cell proliferation can be controlled. Notwithstanding, the observed activities have been time- and dose-dependent. In addition, genistein has also shown varying results in women depending on the physiological parameters, such as the early or post-menopausal states.

【 授权许可】

Unknown