Journal of Pharmacological Sciences | |
Combined Treatment of Ionizing Radiation With Genistein on Cervical Cancer HeLa Cells | |
Jia-yin Liu1  Su-ping Han1  Gang Hu2  Jin-shun Pan2  Bei Zhang1  Xiao-xing Yin2  Bing Wang2  | |
[1] Department of Obstetric and Gynecology, the First Affiliated Hospital, Nanjing Medical University, China;Department of Pharmacology, Nanjing Medical University, China | |
关键词: genistein; ionizing radiation; survivin; apoptosis; cell cycle; | |
DOI : 10.1254/jphs.FP0060165 | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(38)Cited-By(15)The anticancer agent genistein inhibits cell growth of tumor cell lines from various malignancies. In our study, we investigated the effectiveness of combined treatment of ionizing radiation (IR) with genistein on cervical HeLa cells and its possible mechanism. It was found that the inhibitory rate in cells with combined treatment was significantly higher than that of the cells treated with IR or genistein alone. After treatments of IR (4 Gy) combined with genistein (40 μmol/L), the apoptotic index of the cells was significantly increased and the cells were arrested in the G2/M phase. Survivin mRNA expression increased after IR (4 Gy), while it significantly decreased after combined treatment. These findings indicated that genistein enhanced the radiosensitivity of cervical cancer HeLa cells, and the mechanisms for this action might include increase of apoptosis, decrease of survivin expression, and prolongation of cell cycle arrest.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201911300284708ZK.pdf | 531KB | download |