The Potential of Metabolomics in the Diagnosis of Thyroid Cancer

International Journal of Molecular Sciences

John Jones¹  Margarida Coelho¹  Bruno Manadas¹  Luigi Atzori²  BrianJ. Goodfellow³  Luis Raposo⁴ 

[1] CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal;Department of Biomedical Sciences, University of Cagliari, 09042 Cagliari, Italy;Department of Chemistry and CICECO, University of Aveiro, 3810-193 Aveiro, Portugal;Thyroid Study Group, Portuguese Society of Endocrinology, Diabetes and Metabolism, 1600-892 Lisbon, Portugal;

关键词: metabolomics;    thyroid cancer;    biomarker;    metabolite;    diagnosis;   

DOI  :  10.3390/ijms21155272

来源: DOAJ

【 摘 要 】

Thyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of thyroid cancer, but drawbacks to this technique include indeterminate results or an inability to discriminate different carcinomas, thereby requiring additional surgical procedures to obtain a final diagnosis. It is, therefore, necessary to seek more reliable markers to complement and improve current methods. “Omics” approaches have gained much attention in the last decade in the field of biomarker discovery for diagnostic and prognostic characterisation of various pathophysiological conditions. Metabolomics, in particular, has the potential to identify molecular markers of thyroid cancer and identify novel metabolic profiles of the disease, which can, in turn, help in the classification of pathological conditions and lead to a more personalised therapy, assisting in the diagnosis and in the prediction of cancer behaviour. This review considers the current results in thyroid cancer biomarker research with a focus on metabolomics.

【 授权许可】

Unknown