Syncytium calcium signaling and macrophage function in the heart

Cell & Bioscience

Shawn Chen¹  Frederic Chen¹  Hiroshi Takeshima²  Joseph Bryant³  Juan Wang⁴  Xin Zhou⁴  Zhongguang Li⁴  Zefan Wang⁴  Xuehong Xu⁴  Jianjie Ma⁵  Tao Tan⁵  Odell Jones⁶  Eda Chen⁷ 

[1] Chen Wellness Clinics;Graduate School of Pharmaceutical Sciences, Kyoto University;Institute of Human Virology, University of Maryland School of Medicine;Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences;Ohio State University College of Medicine;University of Pennsylvania ULAR;Virginia Commonwealth University College of Medicine;

关键词: Macrophage;    Electrical connection;    Calcium dependency;    Colony-stimulating factors (CSF);    Mononuclear phagocyte system (MPS);   

DOI  :  10.1186/s13578-018-0222-6

来源: DOAJ

【 摘 要 】

Abstract Macrophages are traditionally viewed as a key component of the immunity defense system. Recent studies have identified resident macrophages in multiple organs including the heart, in which the cells perform their crucial role on tissue repair after myocardial infarction (MI). The cardiac-specific macrophages interdigitate with cardiomyocytes particularly at the atrioventricular node region. The integrative communication between macrophage and cardiomyocytes can modulate the contractile function of the heart. Coordinated control of intracellular calcium signaling and intercellular electrical conduction via the syncytium network underlie the synchronized beating of the heart. In this review article, we introduce the concept the syncytium calcium signaling in the cardiomyocytes can modulate gene expression in the resident macrophages and their integration with the cardiomyocytes. The cardiac macrophages originate from bone marrow stem cells, migrate to local via vessel, and settle down as a naturalization process in heart. As the macrophages perform on regulating electrical conduction, and accomplish post MI non-scared completed regeneration or partial regeneration with fibrotic scar at different stage of postnatal development, we understand that multiple functions of cardiac macrophage should carry on with diverse linages. The naturalization process in heart of macrophages to the cardiomyocytes serves important roles to control of electrical signaling and calcium-dependent contractile function of the heart.

【 授权许可】

Unknown