Human Gingival Crevicular Fluids (GCF) Proteomics: An Overview

Dentistry Journal

Shariq Najeeb¹  Maria Mali²  Muhammad Sohail Zafar³  Mustafa Naseem⁴  Zohaib Khurshid⁵ 

[1] Department of Dentistry, Riyadh Consultative Clinics, Riyadh 11313, Saudi Arabia;Department of Orthodontics, Fatima Jinnah Dental College, Karachi 78650, Pakistan;Department of Restorative Dentistry, College of Dentistry, Al-Taibah University, Medina Munawwarah 41311, Saudi Arabia;Preventive Dental Sciences, College of Dentistry, Dar-Al-Uloom University, Riyadh 13314, Saudi Arabia;Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia;

关键词: proteomics;    proteins;    biomarkers;    gingival crevicular fluids (GCFs);    dentistry;   

DOI  :  10.3390/dj5010012

来源: DOAJ

【 摘 要 】

Like other fluids of the human body, a gingival crevicular fluid (GCF) contains proteins, a diverse population of cells, desquamated epithelial cells, and bacteria from adjacent plaque. Proteomic tools have revolutionized the characterization of proteins and peptides and the detection of early disease changes in the human body. Gingival crevicular fluids (GCFs) are a very specific oral cavity fluid that represents periodontal health. Due to their non-invasive sampling, they have attracted proteome research and are used as diagnostic fluids for periodontal diseases and drug analysis. The aim of this review is to explore the proteomic science of gingival crevicular fluids (GCFs), their physiology, and their role in disease detection.

【 授权许可】

Unknown