Proteomics for the Identification of Biomarkers in Testicular Cancer–Review

Frontiers in Endocrinology

Federica Vincenzoni¹  Francesco Pierconti²  Giuseppe Grande³  Domenico Milardi³  Alfredo Pontecorvi³ 

[1] Department of Laboratory Diagnostic and Infectious Diseases, Fondazione Policlinico'A. Gemelli' IRCCS, Rome, Italy;Division of Anatomic Pathology and Histology, School of Medicine, Catholic University of Rome, Rome, Italy;Division of Endocrinology, Fondazione Policlinico'A. Gemelli' IRCCS, Rome, Italy;International Scientific Institute “Paul VI”, Rome, Italy;School of Medicine, Biochemistry and Clinical Biochemistry Institute, Catholic University of Rome, Rome, Italy;

关键词: testis cancer;    proteomics;    biomarker;    germ cell tumor;    proteins;   

DOI  :  10.3389/fendo.2019.00462

来源: DOAJ

【 摘 要 】

A large number of biomarkers have been proposed for the diagnosis of testicular cancer, representing putative molecular targets for anticancer treatments. However, no conclusive data have been provided. Proteomics represents a research field recently developed. It evaluates the large-scale analysis of the full protein components of a single cell, of a specific tissue, or of biological fluids. In the last decades, proteomics has been applied in clinical fields, thanks to modern technology and new bioinformatic tools, to identify novel molecular markers of diseases. The aim of this review is to argue the findings of recent studies in the discoveries of putative prognostic and diagnostic markers of testis cancer by proteomic techniques. We present here a panel of proteins identified by proteomics which might be used after validation for early detection and the prognostic evaluation of testicular tumors. In addition, the molecular mechanisms revealed by these proteomic studies might also guide the development of novel treatments in future.

【 授权许可】

Unknown