Biomarker Discovery by Novel Sensors Based on Nanoproteomics Approaches

Sensors

Noelia Dasilva²  Paula Dໞz²  Sergio Matarraz²  Mar໚ González-González²  Sara Paradinas¹  Alberto Orfao² 

[1] Departamento de Química Analítica, Facultad de Ciencias Químicas, University of Salamanca, Salamanca 37008, Spain; E-Mail:;Centro de Investigación del Cáncer/IBMCC (USAL/CSIC), Departamento de Medicina and Servicio General de Citometría, University of Salamanca, Salamanca 37007, Spain; E-Mails:

关键词: biomarker;    cancer;    nanosensor;    high-throughput techniques;    microarray;    proteomics;   

DOI  :  10.3390/s120202284

来源: mdpi

【 摘 要 】

During the last years, proteomics has facilitated biomarker discovery by coupling high-throughput techniques with novel nanosensors. In the present review, we focus on the study of label-based and label-free detection systems, as well as nanotechnology approaches, indicating their advantages and applications in biomarker discovery. In addition, several disease biomarkers are shown in order to display the clinical importance of the improvement of sensitivity and selectivity by using nanoproteomics approaches as novel sensors.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland