Molecular Insights Into Development and Virulence Determinants of Aspergilli: A Proteomic Perspective

Frontiers in Cellular and Infection Microbiology

Shanu Hoda¹  Pooja Vijayaraghavan¹  Shraddha Tiwari²  Sonia K. Shishodia²  Manali Gangwar²  Raman Thakur²  Jata Shankar² 

[1] Amity Institute of Biotechnology, Amity University, Noida, India;Genomic Laboratory, Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Solan, India;

关键词: Aspergilli;    conidia;    germinating conidia;    proteins;    secondary metabolites;    proteomics;   

DOI  :  10.3389/fcimb.2018.00180

来源: DOAJ

【 摘 要 】

Aspergillus species are the major cause of health concern worldwide in immunocompromised individuals. Opportunistic Aspergilli cause invasive to allergic aspergillosis, whereas non-infectious Aspergilli have contributed to understand the biology of eukaryotic organisms and serve as a model organism. Morphotypes of Aspergilli such as conidia or mycelia/hyphae helped them to survive in favorable or unfavorable environmental conditions. These morphotypes contribute to virulence, pathogenicity and invasion into hosts by excreting proteins, enzymes or toxins. Morphological transition of Aspergillus species has been a critical step to infect host or to colonize on food products. Thus, we reviewed proteins from Aspergilli to understand the biological processes, biochemical, and cellular pathways that are involved in transition and morphogenesis. We majorly analyzed proteomic studies on A. fumigatus, A. flavus, A. terreus, and A. niger to gain insight into mechanisms involved in the transition from conidia to mycelia along with the role of secondary metabolites. Proteome analysis of morphotypes of Aspergilli provided information on key biological pathways required to exit conidial dormancy, consortia of virulent factors and mycotoxins during the transition. The application of proteomic approaches has uncovered the biological processes during development as well as intermediates of secondary metabolite biosynthesis pathway. We listed key proteins/ enzymes or toxins at different morphological types of Aspergillus that could be applicable in discovery of novel therapeutic targets or metabolite based diagnostic markers.

【 授权许可】

Unknown