Redox Homeostasis and Natural Dietary Compounds: Focusing on Antioxidants of Rice (Oryza sativa L.)

Nutrients

Wiramon Rungratanawanich¹  Maurizio Memo¹  Daniela Uberti¹ 

[1] Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy;

关键词: natural compound;    phytochemical;    rice;    Oryza sativa L.;    γ-oryzanol;    redox homeostasis;    Nrf2;    oxidative stress;    ROS;    antioxidant;   

DOI  :  10.3390/nu10111605

来源: DOAJ

【 摘 要 】

Redox homeostasis may be defined as the dynamic equilibrium between electrophiles and nucleophiles to maintain the optimum redox steady state. This mechanism involves complex reactions, including nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, activated by oxidative stress in order to restore the redox balance. The ability to maintain the optimal redox homeostasis is fundamental for preserving physiological functions and preventing phenotypic shift toward pathological conditions. Here, we reviewed mechanisms involved in redox homeostasis and how certain natural compounds regulate the nucleophilic tone. In addition, we focused on the antioxidant properties of rice and particularly on its bioactive compound, γ-oryzanol. It is well known that γ-oryzanol exerts a variety of beneficial effects mediated by its antioxidant properties. Recently, γ-oryzanol was also found as a Nrf2 inducer, resulting in nucleophilic tone regulation and making rice a para-hormetic food.

【 授权许可】

Unknown