Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention

Biomedicines

Md.Shahadat Hossain¹  MD.Hasanur Rahman¹  Partha Biswas¹  MdJamal Uddin¹  Hyewhon Rhim²  Md.Ataur Rahman²  Md.Habibur Rahman³  Rokibul Islam⁴ 

[1] ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh;Center for Neuroscience, Korea Institute of Science and Technology (KIST), 5 Hwarang-ro 14-gil, Seoul 02792, Korea;Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Seoul 03722, Korea;Global Biotechnology & Biomedical Research Network (GBBRN), Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh;

关键词: autophagy;    cancer;    phytochemical;    natural compound;    treatment;   

DOI  :  10.3390/biomedicines8110517

来源: DOAJ

【 摘 要 】

Autophagy is a vacuolar, lysosomal degradation pathway for injured and damaged protein molecules and organelles in eukaryotic cells, which is controlled by nutrients and stress responses. Dysregulation of cellular autophagy may lead to various diseases such as neurodegenerative disease, obesity, cardiovascular disease, diabetes, and malignancies. Recently, natural compounds have come to attention for being able to modulate the autophagy pathway in cancer prevention, although the prospective role of autophagy in cancer treatment is very complex and not yet clearly elucidated. Numerous synthetic chemicals have been identified that modulate autophagy and are favorable candidates for cancer treatment, but they have adverse side effects. Therefore, different phytochemicals, which include natural compounds and their derivatives, have attracted significant attention for use as autophagy modulators in cancer treatment with minimal side effects. In the current review, we discuss the promising role of natural compounds in modulating the autophagy pathway to control and prevent cancer, and provide possible therapeutic options.

【 授权许可】

Unknown