Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Frontiers in Pharmacology

Pharmacology

Wonyoung Park¹  Ki-Tae Ha¹  Eun-Ji Lee²  Jung Ho Han²  Hwan-Suck Chung³ 

[1] Korean Convergence Medical Science Major, KIOM Campus, University of Science and Technology (UST), Daegu, Republic of Korea;Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, Republic of Korea;Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, Republic of Korea;Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea;

关键词: lactate dehydrogenase;    natural compound;    LDH inhibitor;    pharmacological effect;    cancer;    cardiovascular disease;    neurodegenerative disease;   

DOI  :  10.3389/fphar.2023.1275000

 received in 2023-08-09, accepted in 2023-09-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases. Targeting LDH has emerged as a vital approach in drug discovery, leading to the identification of LDH inhibitors among natural compounds, such as polyphenols, alkaloids, and terpenoids. These compounds demonstrate therapeutic potential against LDH-related diseases, including anti-cancer effects. However, challenges concerning limited bioavailability, poor solubility, and potential toxicity must be addressed. Combining natural compounds with LDH inhibitors has led to promising outcomes in preclinical studies. This review highlights the promise of natural compounds as LDH inhibitors for treating cancer, cardiovascular, and neurodegenerative diseases.

【 授权许可】

Unknown   
Copyright © 2023 Han, Lee, Park, Ha and Chung.

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