Correlation between Electrode Location and Anxiety Depression of Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

Brain Sciences

Jian-Guo Zhang¹  Fan-Gang Meng¹  Dong-Mei Gao¹  Chun-Lei Han¹  Shi-Ying Fan¹  Yu-Jing Xing²  Cong-Hui Li²  Ji-Wei Wang²  Feng Zhang²  Chen Yang²  Man-Man Yang²  Feng Wang³ 

[1] Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;Department of Neurosurgery, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China;Departments of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China;

关键词: Parkinson’s disease;    subthalamic nucleus;    deep brain stimulation;    anxiety;    depression;    volume of tissue activated;   

DOI  :  10.3390/brainsci12060755

来源: DOAJ

【 摘 要 】

Objectives: our group explored the correlation between postoperative coordinates of the electrode contacts, VTA, and anxiety and depression symptoms in Parkinson’s disease (PD) patients after subthalamic nucleus deep brain stimulation (STN-DBS). Methods: STN-DBS was conducted on PD patients (n = 57) for six months with follow-up. Clinical outcomes were explored using the unified Parkinson’s disease rating scale Part III (UPDRS-III), the Hamilton Anxiety Rating Scale (HAM-A), and the Hamilton Depression Rating Scale (HAM-D) before and after surgery. At the Montreal Neurological Institute (MNI), the location of active contacts and the volume of tissue activated (VTA) were calculated. Results: patient evaluations took place preoperatively and follow-ups took place at 1 month, 3 months, and 6 months. The average patient improvement rates for HAM-A and HAM-D scores at the 6-month follow-up were 41.7% [interquartile range (IQR) 34.9%] and 37.5% (IQR 33.4%), respectively (both p < 0.001). In medication-off, there were negative correlations between the HAM-A improvement rate and the Z-axis coordinate of the active contact (left side: r = −0.308, p = 0.020; right side: r = −0.390, p = 0.003), and negative correlations between the HAM-D improvement rate and the Z-axis coordinate of the active contact (left side: r = −0.345, p = 0.009; right side: r = −0.521, p = 0.001). There were positive correlations between the HAM-A and HAM-D scores improvement rate at 6 months after surgery and bilateral VTA in the right STN limbic subregion (HAM-A: r = 0.314, p = 0.018; HAM-D: r = 0.321, p = 0.015). Conclusion: bilateral STN-DBS can improve anxiety and depression symptoms in PD patients. The closer the stimulation to the ventral limbic region of the STN, the more significant the improvement in anxiety and depression symptoms of PD patients.

【 授权许可】

Unknown