Movement-Related Activity of Human Subthalamic Neurons during a Reach-to-Grasp Task

Frontiers in Human Neuroscience

Günther Deuschl¹  Jan Arne Heiden¹  Jan Herzog¹  Uri Ramirez-Pasos²  Jens Volkmann²  Frank Steigerwald²  Monika Pötter-Nerger³  Christian Gerloff³  Rene Reese⁴  Christian K. E. Moll⁵  Maximilian Mehdorn⁶  Daniela Falk⁶  Wolfgang Hamel⁷ 

[1] Department of Neurology, Christian-Albrechts-UniversityKiel, Germany;Department of Neurology, Julius-Maximilian UniversityWürzburg, Germany;Department of Neurology, University Hamburg-EppendorfHamburg, Germany;Department of Neurology, University RostockRostock, Germany;Department of Neurophysiology, University Hamburg-EppendorfHamburg, Germany;Department of Neurosurgery, Christian-Albrechts-UniversityKiel, Germany;Department of Neurosurgery, University Hamburg-EppendorfHamburg, Germany;

关键词: subthalamic nucleus;    deep brain stimulation;    Parkinson’s disease;    neurophysiology;    beta oscillation;    reach-to-grasp movement;   

DOI  :  10.3389/fnhum.2017.00436

来源: DOAJ

【 摘 要 】

The aim of the study was to record movement-related single unit activity (SUA) in the human subthalamic nucleus (STN) during a standardized motor task of the upper limb. We performed microrecordings from the motor region of the human STN and registered kinematic data in 12 patients with Parkinson’s disease (PD) undergoing deep brain stimulation surgery (seven women, mean age 62.0 ± 4.7 years) while they intraoperatively performed visually cued reach-to-grasp movements using a grip device. SUA was analyzed offline in relation to different aspects of the movement (attention, start of the movement, movement velocity, button press) in terms of firing frequency, firing pattern, and oscillation. During the reach-to-grasp movement, 75/114 isolated subthalamic neurons exhibited movement-related activity changes. The largest proportion of single units showed modulation of firing frequency during several phases of the reach and grasp (polymodal neurons, 45/114), particularly an increase of firing rate during the reaching phase of the movement, which often correlated with movement velocity. The firing pattern (bursting, irregular, or tonic) remained unchanged during movement compared to rest. Oscillatory single unit firing activity (predominantly in the theta and beta frequency) decreased with movement onset, irrespective of oscillation frequency. This study shows for the first time specific, task-related, SUA changes during the reach-to-grasp movement in humans.

【 授权许可】

Unknown