Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects

eLife

Todd M Herrington¹  Alik S Widge²  Jimmy C Yang³  Alice W Flaherty³  Sarah K Bick³  Shaun R Patel³  Darin Dougherty⁴  Sameer A Sheth⁵  Michael J Frank⁵  Matthew Mian⁶  Emad N Eskandar⁷ 

[1] Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, United States;Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, United States;Department Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, United States;Department of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, United States;Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, United States;Department of Neurosurgery, Baylor College of Medicine, Houston, United States;Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, United States;

关键词: subthalamic nucleus;    neurophysiology;    fMRI;    human;    decision-making;    deep brain stimulation;   

DOI  :  10.7554/eLife.36460

来源: DOAJ

【 摘 要 】

The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.

【 授权许可】

Unknown