eLife | |
Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects | |
Todd M Herrington1  Alik S Widge2  Jimmy C Yang3  Alice W Flaherty3  Sarah K Bick3  Shaun R Patel3  Darin Dougherty4  Sameer A Sheth5  Michael J Frank5  Matthew Mian6  Emad N Eskandar7  | |
[1] Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, United States;Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, United States;Department Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, United States;Department of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, United States;Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, United States;Department of Neurosurgery, Baylor College of Medicine, Houston, United States;Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, United States; | |
关键词: subthalamic nucleus; neurophysiology; fMRI; human; decision-making; deep brain stimulation; | |
DOI : 10.7554/eLife.36460 | |
来源: DOAJ |
【 摘 要 】
The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers.
【 授权许可】
Unknown