Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity

Anais da Academia Brasileira de Ciências

关键词: antitumor activity;    chemical modification;    derivative synthesis;    natural products esters;   

DOI  :  10.1590/0001-3765201720160780

来源: DOAJ

【 摘 要 】

ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.

【 授权许可】

Unknown