Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents

Molecules

Yujin Zhu¹  Yanjun Zhang¹  Yi Liu¹  Hongwan Chu¹ 

[1] ¹School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China ²Chinese People’s Armed Police Forces, Tianjin Provincial Corps Hospital, Tianjin 300162, China ³Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

关键词: trans-tiliroside;    derivative synthesis;    Novozyme435;    anti-diabetic activity;   

DOI  :  10.3390/molecules15129174

来源: mdpi

【 摘 要 】

A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, ¹H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.