MPT64 assays for the rapid detection of Mycobacterium tuberculosis

BMC Infectious Diseases

Jia-Ying Wang¹  Jie Zhou¹  Xun-Jie Cao¹  Xu-Guang Guo¹  Ya-Ping Li¹ 

[1] Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University;

关键词: MPT64;    Mycobacterium tuberculosis;    Tuberculosis;    MTB;    Commercial kits;   

DOI  :  10.1186/s12879-021-06022-w

来源: DOAJ

【 摘 要 】

Abstract Background Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB). An estimated 1.7 billion people worldwide are infected with Mycobacterium tuberculosis (LTBI) during the incubation period without any obvious symptoms. Because of MTB’s high infection and mortality rates, there is an urgent need to develop a fast, portable, and sensitive diagnostic technology for its detection. Methods We included research from PubMed, Cochrane Library, Web of Science, and Embase and extracted the data. MetaDisc and STATA were used to build forest plots, Deek’s funnel plot, Fagan plot, and bivariate boxplot for analysis. Results Forty-six articles were analyzed, the results of which are as follows: sensitivity and specificity were 0.92 (0.91–0.93) and 0.95 (0.94–0.95) respectively. The NLR and PLR were 0.04 (95% CI 0.03–0.07) and 25.32 (95% CI 12.38–51.78) respectively. DOR was 639.60 (243.04–1683.18). The area under the SROC curve (AUC) was 0.99. Conclusions MPT64 exhibits good diagnostic efficiency for MTB. There is no obvious heterogeneity between the three commercial kits.

【 授权许可】

Unknown