MPT64 assays for the rapid detection of Mycobacterium tuberculosis

BMC Infectious Diseases

Jia-Ying Wang¹  Jie Zhou¹  Xun-Jie Cao¹  Ya-Ping Li²  Xu-Guang Guo³ 

[1] Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, China;Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, 511436, Guangzhou, China;Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, China;Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, 511436, Guangzhou, China;Department of Clinical Medicine, The Second Clinical School of Guangzhou Medical University, 511436, Guangzhou, China;Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, China;Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, 511436, Guangzhou, China;Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, China;Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, China;

关键词: MPT64;    Mycobacterium tuberculosis;    Tuberculosis;    MTB;    Commercial kits;   

DOI  :  10.1186/s12879-021-06022-w

来源: Springer

【 摘 要 】

BackgroundTuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (MTB). An estimated 1.7 billion people worldwide are infected with Mycobacterium tuberculosis (LTBI) during the incubation period without any obvious symptoms. Because of MTB’s high infection and mortality rates, there is an urgent need to develop a fast, portable, and sensitive diagnostic technology for its detection.MethodsWe included research from PubMed, Cochrane Library, Web of Science, and Embase and extracted the data. MetaDisc and STATA were used to build forest plots, Deek’s funnel plot, Fagan plot, and bivariate boxplot for analysis.ResultsForty-six articles were analyzed, the results of which are as follows: sensitivity and specificity were 0.92 (0.91–0.93) and 0.95 (0.94–0.95) respectively. The NLR and PLR were 0.04 (95% CI 0.03–0.07) and 25.32 (95% CI 12.38–51.78) respectively. DOR was 639.60 (243.04–1683.18). The area under the SROC curve (AUC) was 0.99.ConclusionsMPT64 exhibits good diagnostic efficiency for MTB. There is no obvious heterogeneity between the three commercial kits.

【 授权许可】

CC BY