Safety assessment of Streptococcus thermophilus IDCC 2201 used for product manufacturing in Korea

Food Science & Nutrition

Jungwoo Yang¹  Seung A Chae¹  O‐Hyun Ban¹  Sangki Oh¹  Soo‐Yeon Yang¹  Chanmi Park¹  Bo Som Lee²  Young Hoon Jung²  Won Yeong Bang² 

[1] Ildong Bioscience Gyeonggi‐do South Korea;School of Food Science and Biotechnology Kyungpook National University Daegu South Korea;

关键词: Antibiotic resistance;    Probiotics;    Safety evaluation;    Single‐dose oral toxicity;    Streptococcus thermophilus;   

DOI  :  10.1002/fsn3.1925

来源: DOAJ

【 摘 要 】

Abstract Safety evaluation of probiotics has become increasingly important for human consumption in food industry. The aims of this study were to assess safety of Streptococcus thermophilus IDCC 2201 through in vitro and in vivo tests. In results, this strain was found to be negative for hemolytic and β‐glucuronidase activity. In addition, thermophilus IDCC 2201 was susceptible to nine antibiotics suggested by EFSA. In accordance with MIC tests, whole‐genome analysis indicated that S. thermophilus IDCC 2201 neither harbors antibiotic resistance nor toxigenic genes. Furthermore, none of the biogenic amines including tyramine and histamine was produced and negligible amounts of D‐lactate were produced by S. thermophilus IDCC 2201. Finally, it was confirmed that there was no mortality and toxicity throughout single‐dose oral toxicity tests in rats. Therefore, we report that S. thermophilus IDCC 2201 is considered to be safe for human consumption as probiotics.

【 授权许可】

Unknown